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Amyloid precursor protein
アミロイド前駆体タンパク質（アミロイドぜんくたいタンパクしつ、英: amyloid precursor protein 、略称: APP）またはアミロイドβ前駆体タンパク質は、多くの組織で発現している内在性膜タンパク質で、神経細胞のシナプスに濃縮されている。. APP processing and amyloid-β production play a central role in Alzheimer disease pathogenesis. In addition to amyloid-β, α- or β-secretase-dependent cleavage of APP also generates soluble secreted APP (APPsα or APPsβ, respectively). These plaques are a hallmark of Alzheimer's disease.
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