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Some early research suggests that benfotiamine on its own or with other B vitamins might ease symptoms of nerve damage, or neuropathy, in people with type 1 or type 2 diabetes. But the studies were small and lasted only weeks. Other research has found no benefits to the nerves.
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Tell them about any medications or other supplements you take. They can check to see if benfotiamine might affect the way your meds work. Ask your doctor which brand you should buy, and how much and for how long you should use it.
Because benfotiamine is a dietary supplement the FDA only requires manufacturers and distributors to have credible evidence as to its safety. The FDA itself has not evaluated benfotiamine for safety or effectiveness. Benfotiamine therefore cannot be represented to diagnose, treat, cure, or prevent any disease. For more information on this and related topics, please review our FAQ's on benfotiamine for more information. THE STATEMENTS MADE BY BENFOCOMPLETE HAVE NOT BEEN EVALUATED BY THE FDA (U.S. FOOD & DRUG ADMINISTRATION). OUR PRODUCTS ARE NOT INTENDED TO DIAGNOSE, CURE OR PREVENT ANY DISEASE. BENFOTIAMINE.NET, INC. IS NOT AFFILIATED WITH ANY OF THE STUDIES MENTIONED ON THE WEBSITE. THE TESTIMONIALS ON THIS WEBSITE ARE INDIVIDUAL CASES AND DO NOT GUARANTEE THAT YOU WILL GET THE SAME RESULTS.
Benfotiamine is a derivative of vitamin B1 (thiamine). While B vitamins are naturally water-soluble, synthesized benfotiamine is fat-soluble. Once ingested, ecto-alkaline phosphatases dephosphorylate benfotiamine into S-benzoylthiamine, which thioesters enzymes hydrolyze into thiamine in the liver. Benfotiamine is stable and easier for the body to absorb than thiamine salts.
Benfotiamine does not appear to cause notable side effects based on the available scientific literature. However, some individuals may experience dizziness, nausea, or a dip in blood pressure. Individuals with sulfur sensitivities or allergies should not take benfotiamine, as it contains sulfur. Individuals should consult with a physician before taking new supplements.
Benfotiamine is a potent allithiamine, a group of thiamine (vitamin B1) derivatives. Compared with thiamine, benfotiamine has a highly specific structure which offers benefits for our health. For example, studies show that it passes through cell membranes more easily, remaining longer in the body, and thus presenting excellent bioavailability. Benfotiamine is therefore often considered a bioavailable and absorbable form of vitamin B1.
As well as preventing or correcting vitamin B1 deficiency, supplementing with benfotiamine also offers significant therapeutic potential. In fact, a lack of thiamine can be observed in several diseases which is why it is now used in a preventive or therapeutic capacity, in, amongst others:
Given the importance of vitamin B1 to our health, our dietary supplement Benfotiamine has been specifically formulated to prevent the risk of deficiency. Inadequate intake or poor absorption of the vitamin can lead to deficiency and subsequent health problems. A lack of vitamin B1 is particularly common in alcoholics, people suffering from chronic intestinal diseases or acute infections, those taking diuretics or those who eat a lot of carbohydrates. In the absence of sufficient B1, deficiency can manifest in loss of appetite, weight loss and fatigue. In more serious cases, thiamine deficiency can trigger diseases such as beriberi. This is characterized by neurological impairment with reduced mental capacity, mobility problems, disturbed balance and even psychosis. Supplementing with benfotiamine can thus prove vital in preventing deficiency in vitamin B1.
Our benfotiamine supplement has been developed to provide an optimal level of vitamin B1. Each capsule contains 80 mg of benfotiamine, providing 55 mg of elemental thiamine, with a suggested dose of 2-4 capsules a day to be taken with meals. This dose can, however, be adjusted in line with your needs and the advice of your therapist.
Bönhof GJ, Sipola G, Strom A, et al. BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy. BMJ Open. 2022;12(2):e057142. Published 2022 Feb 3. doi:10.1136/bmjopen-2021-057142
Manzardo AM, Pendleton T, Poje A, Penick EC, Butler MG. Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity. Drug Alcohol Depend. 2015;152:257-263. doi:10.1016/j.drugalcdep.2015.03.032
Allowitz KV, Yoo JJ, Taylor JR, Baloch OA, Harames K, Ramana KV. Therapeutic potential of vitamin B1 derivative benfotiamine from diabetes to COVID-19. Future Med Chem. 2022;14(11):809-826. doi:10.4155/fmc-2022-0040
Oh SH, Witek RP, Bae SH, Darwiche H, Jung Y, Pi L, Brown A, Petersen BE. Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism. Stem Cells Dev. 2009. 18(1):37-46. doi:10.1089/scd.2007.0255
Benfotiamine is the pre-stage of thiamine also known as vitamin B1. The liposoluble benfotiamine is characterized by a significantly better bioavailability compared to the water-soluble thiamine. In the organism benfotiamine is quickly converted into vitamin B1. Thiamine has numerous functions in the body. It is significant for the energy production from carbohydrates and proteins. Additionally, it plays a role in the stimulus conduction thus having an important role in the nervous system. Due to a more effective incorporation benfotiamine can adjust a vitamin B1 deficiency faster. Benfotiamine 300 mg GPH capsules contain 300 mg synthetically produces benfotiamine; vitamin B1 is used as a base material.
Promote healthy nerve function with Dr. Berg Nerve Support. This unique formula is packed with eight incredible nutrients that promote a healthy nervous system, including benfotiamine. If you want a formula that offers full nervous system support, this supplement is perfect for you. Each bottle contains 90 potent capsules.
Dr. Berg Nerve Support is designed to promote the health of your entire nervous system using eight powerful ingredients, including benfotiamine, folate, magnesium, alpha-lipoic acid, and vitamins D3, B2, B6, and B12. These ingredients are excellent for reducing oxidative stress, lowering inflammation, and supporting normal nerve function.
Vitamin B1 has been used for decades to treat neurological conditions, in particular diabetic neuropathy. A deficiency in thiamine is commonly noted in patients with diabetic neuropathy, as well as those that have developed neuropathies due to malabsorption. Benfotiamine is a fat-soluble form of thiamine (vitamin B1) that has demonstrated improved absorption, higher blood levels, and longer maintained blood and tissue concentrations as compared to the more common water-soluble thiamine. Once absorbed, benfotiamine is rapidly converted to the biologically active thiamine. Interestingly, benfotiamine, which has been used in Germany, and is now available without a prescription, supports nerve health for those with diabetes-induced nerve damage.
Various studies have been done on the use of benfotiamine in diabetic neuropathy patients, including the use of benfotiamine in combination with additional B vitamins. The best patient response was seen in studies that used a larger daily dose of benfotiamine. Treatment was well tolerated by patients, and no benfotiamine-drug interactions were reported. A study of 20 patients given 400mg daily of benfotiamine showed improvement in neuropathy scores and decrease in pain complaints over a 3-week period. Another study compared benfotiamine treatment doses of 300mg versus 600mg over a 6-week duration, finding that improvement was more pronounced at the higher benfotiamine dose and increased with treatment length.
A combination nutritional formulation may provide patients with an economical advantage as they can combine multiple ingredients targeting nerve health into one product. These combination products may include lipoic acid, acetyl L-carnitine, vitamin B6, vitamin B12, and folate, in addition to benfotiamine. Speak with a pharmacist to find out which high-quality professional grade nutritional supplement company they recommend.
Mega Benfotiamine is formulated with 250 mg of benfotiamine and 10 mg of thiamine (vitamin B1) to support healthy blood sugar metabolism. It also helps protect your body against oxidative stress and glycation, a biochemical reaction that can contribute to a variety of age-related factors.
Benfotiamine may also be more helpful in certain situations than thiamine: for example, the enzyme transketolase is critical to blood sugar metabolism and requires thiamine as a cofactor. Unfortunately, the water-soluble thiamine is less available to the interior of the cell, while benfotiamine is fat-soluble and can easily penetrate the cell membrane.
Benfotiamine is also more bioavailable than the water-soluble thiamine. In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways. Benfotiamine also blocked the activation of the transcription factor known as nuclear factor-kappa B (NF-kB).
Overall, benfotiamine can modulate glucose metabolism and promote healthy blood glucose levels already within the normal range. By doing so, benfotiamine also helps inhibit the formation of AGEs and supports healthy endothelial function.
There are many different mechanisms involved in maintaining our eye and overall health. Some nutrients can play several roles and support our health in different facets. Benfotiamine, a variant of Vitamin B1 (thiamine), is one of those ingredients that works for our bodies in a multitude of fashions. Here are a few ways that benfotiamine can help you. 041b061a72